diff --git a/src/conf/domain_conf.c b/src/conf/domain_conf.c
index 4ed354c907..0219c3c481 100644
--- a/src/conf/domain_conf.c
+++ b/src/conf/domain_conf.c
@@ -12658,8 +12658,7 @@ virDomainDiskDefDstDuplicates(virDomainDefPtr def)
 
     for (i = 1; i < def->ndisks; i++) {
         for (j = 0; j < i; j++) {
-            if (def->disks[i]->bus == def->disks[j]->bus &&
-                STREQ(def->disks[i]->dst, def->disks[j]->dst)) {
+            if (STREQ(def->disks[i]->dst, def->disks[j]->dst)) {
                 virReportError(VIR_ERR_XML_ERROR,
                                _("target '%s' duplicated for disk sources "
                                  "'%s' and '%s'"),
diff --git a/tests/qemuxml2argvdata/qemuxml2argv-disk-same-targets.xml b/tests/qemuxml2argvdata/qemuxml2argv-disk-same-targets.xml
new file mode 100644
index 0000000000..3276ce5877
--- /dev/null
+++ b/tests/qemuxml2argvdata/qemuxml2argv-disk-same-targets.xml
@@ -0,0 +1,35 @@
+<domain type='qemu'>
+  <name>QEMUGuest1</name>
+  <uuid>c7a5fdbd-edaf-9455-926a-d65c16db1809</uuid>
+  <memory unit='KiB'>219136</memory>
+  <currentMemory unit='KiB'>219136</currentMemory>
+  <vcpu placement='static'>1</vcpu>
+  <os>
+    <type arch='i686' machine='pc'>hvm</type>
+    <boot dev='hd'/>
+  </os>
+  <clock offset='utc'/>
+  <on_poweroff>destroy</on_poweroff>
+  <on_reboot>restart</on_reboot>
+  <on_crash>destroy</on_crash>
+  <devices>
+    <emulator>/usr/bin/qemu</emulator>
+    <disk type='block' device='disk'>
+      <source dev='/dev/HostVG/QEMUGuest1'/>
+      <target dev='hda' bus='ide'/>
+    </disk>
+    <disk type='file' device='disk'>
+      <source file='/tmp/usbdisk.img'/>
+      <target dev='sda' bus='usb'/>
+    </disk>
+    <disk type='file' device='disk'>
+      <source file='/tmp/idedisk.img'/>
+      <target dev='sda' bus='ide'/>
+    </disk>
+    <disk type='file' device='disk'>
+      <source file='/tmp/scsidisk.img'/>
+      <target dev='sda' bus='scsi'/>
+    </disk>
+    <memballoon model='virtio'/>
+  </devices>
+</domain>
diff --git a/tests/qemuxml2argvtest.c b/tests/qemuxml2argvtest.c
index 24c1f301e4..f5cbe3a17c 100644
--- a/tests/qemuxml2argvtest.c
+++ b/tests/qemuxml2argvtest.c
@@ -903,6 +903,9 @@ mymain(void)
             QEMU_CAPS_DEVICE);
     DO_TEST("disk-snapshot",
             QEMU_CAPS_DRIVE, QEMU_CAPS_DRIVE_CACHE_V2, QEMU_CAPS_DRIVE_FORMAT);
+    DO_TEST_FAILURE("disk-same-targets",
+                    QEMU_CAPS_DRIVE, QEMU_CAPS_DEVICE, QEMU_CAPS_SCSI_LSI,
+                    QEMU_CAPS_DEVICE_USB_STORAGE, QEMU_CAPS_NODEFCONFIG);
     DO_TEST("event_idx",
             QEMU_CAPS_DRIVE,
             QEMU_CAPS_VIRTIO_BLK_EVENT_IDX,