diff --git a/src/qemu/qemu_domain.c b/src/qemu/qemu_domain.c
index bcdd518be6..4b467afa81 100644
--- a/src/qemu/qemu_domain.c
+++ b/src/qemu/qemu_domain.c
@@ -62,6 +62,7 @@
 #include "virdomaincheckpointobjlist.h"
 #include "backup_conf.h"
 #include "virutil.h"
+#include "virdevmapper.h"
 
 #ifdef __linux__
 # include <sys/sysmacros.h>
@@ -14623,6 +14624,9 @@ qemuDomainSetupDisk(virQEMUDriverConfigPtr cfg G_GNUC_UNUSED,
     bool hasNVMe = false;
 
     for (next = disk->src; virStorageSourceIsBacking(next); next = next->backingStore) {
+        VIR_AUTOSTRINGLIST targetPaths = NULL;
+        size_t i;
+
         if (next->type == VIR_STORAGE_TYPE_NVME) {
             g_autofree char *nvmePath = NULL;
 
@@ -14641,6 +14645,19 @@ qemuDomainSetupDisk(virQEMUDriverConfigPtr cfg G_GNUC_UNUSED,
 
             if (qemuDomainCreateDevice(next->path, data, false) < 0)
                 return -1;
+
+            if (virDevMapperGetTargets(next->path, &targetPaths) < 0 &&
+                errno != ENOSYS && errno != EBADF) {
+                virReportSystemError(errno,
+                                     _("Unable to get devmapper targets for %s"),
+                                     next->path);
+                return -1;
+            }
+
+            for (i = 0; targetPaths && targetPaths[i]; i++) {
+                if (qemuDomainCreateDevice(targetPaths[i], data, false) < 0)
+                    return -1;
+            }
         }
     }
 
@@ -15656,21 +15673,19 @@ qemuDomainNamespaceSetupDisk(virDomainObjPtr vm,
                              virStorageSourcePtr src)
 {
     virStorageSourcePtr next;
-    char **paths = NULL;
+    VIR_AUTOSTRINGLIST paths = NULL;
     size_t npaths = 0;
     bool hasNVMe = false;
-    g_autofree char *dmPath = NULL;
-    g_autofree char *vfioPath = NULL;
-    int ret = -1;
 
     for (next = src; virStorageSourceIsBacking(next); next = next->backingStore) {
+        VIR_AUTOSTRINGLIST targetPaths = NULL;
         g_autofree char *tmpPath = NULL;
 
         if (next->type == VIR_STORAGE_TYPE_NVME) {
             hasNVMe = true;
 
             if (!(tmpPath = virPCIDeviceAddressGetIOMMUGroupDev(&next->nvme->pciAddr)))
-                goto cleanup;
+                return -1;
         } else {
             if (virStorageSourceIsEmpty(next) ||
                 !virStorageSourceIsLocalStorage(next)) {
@@ -15681,30 +15696,35 @@ qemuDomainNamespaceSetupDisk(virDomainObjPtr vm,
             tmpPath = g_strdup(next->path);
         }
 
-        if (VIR_APPEND_ELEMENT(paths, npaths, tmpPath) < 0)
-            goto cleanup;
+        if (virStringListAdd(&paths, tmpPath) < 0)
+            return -1;
+
+        if (virDevMapperGetTargets(next->path, &targetPaths) < 0 &&
+            errno != ENOSYS && errno != EBADF) {
+            virReportSystemError(errno,
+                                 _("Unable to get devmapper targets for %s"),
+                                 next->path);
+            return -1;
+        }
+
+        if (virStringListMerge(&paths, &targetPaths) < 0)
+            return -1;
     }
 
     /* qemu-pr-helper might require access to /dev/mapper/control. */
-    if (src->pr) {
-        dmPath = g_strdup(QEMU_DEVICE_MAPPER_CONTROL_PATH);
-        if (VIR_APPEND_ELEMENT_COPY(paths, npaths, dmPath) < 0)
-            goto cleanup;
-    }
+    if (src->pr &&
+        virStringListAdd(&paths, QEMU_DEVICE_MAPPER_CONTROL_PATH) < 0)
+        return -1;
 
-    if (hasNVMe) {
-        vfioPath = g_strdup(QEMU_DEV_VFIO);
-        if (VIR_APPEND_ELEMENT(paths, npaths, vfioPath) < 0)
-            goto cleanup;
-    }
+    if (hasNVMe &&
+        virStringListAdd(&paths, QEMU_DEV_VFIO) < 0)
+        return -1;
 
+    npaths = virStringListLength((const char **) paths);
     if (qemuDomainNamespaceMknodPaths(vm, (const char **) paths, npaths) < 0)
-        goto cleanup;
+        return -1;
 
-    ret = 0;
- cleanup:
-    virStringListFreeCount(paths, npaths);
-    return ret;
+    return 0;
 }
 
 
diff --git a/src/util/virdevmapper.h b/src/util/virdevmapper.h
index e576d2bf7e..87bbc63cfd 100644
--- a/src/util/virdevmapper.h
+++ b/src/util/virdevmapper.h
@@ -20,6 +20,8 @@
 
 #pragma once
 
+#include "internal.h"
+
 int
 virDevMapperGetTargets(const char *path,
-                       char ***devPaths);
+                       char ***devPaths) G_GNUC_NO_INLINE;
diff --git a/src/util/virutil.h b/src/util/virutil.h
index cc6b82a177..ee23f0c1f4 100644
--- a/src/util/virutil.h
+++ b/src/util/virutil.h
@@ -120,7 +120,7 @@ bool virValidateWWN(const char *wwn);
 
 int virGetDeviceID(const char *path,
                    int *maj,
-                   int *min);
+                   int *min) G_GNUC_NO_INLINE;
 int virSetDeviceUnprivSGIO(const char *path,
                            const char *sysfs_dir,
                            int unpriv_sgio);
diff --git a/tests/qemuhotplugmock.c b/tests/qemuhotplugmock.c
index 43a9d79051..8e5b07788d 100644
--- a/tests/qemuhotplugmock.c
+++ b/tests/qemuhotplugmock.c
@@ -19,7 +19,24 @@
 #include <config.h>
 
 #include "qemu/qemu_hotplug.h"
+#include "qemu/qemu_process.h"
 #include "conf/domain_conf.h"
+#include "virdevmapper.h"
+#include "virutil.h"
+#include "virmock.h"
+
+static int (*real_virGetDeviceID)(const char *path, int *maj, int *min);
+static bool (*real_virFileExists)(const char *path);
+
+static void
+init_syms(void)
+{
+    if (real_virFileExists)
+        return;
+
+    VIR_MOCK_REAL_INIT(virGetDeviceID);
+    VIR_MOCK_REAL_INIT(virFileExists);
+}
 
 unsigned long long
 qemuDomainGetUnplugTimeout(virDomainObjPtr vm G_GNUC_UNUSED)
@@ -31,3 +48,61 @@ qemuDomainGetUnplugTimeout(virDomainObjPtr vm G_GNUC_UNUSED)
         return 200;
     return 100;
 }
+
+
+int
+virDevMapperGetTargets(const char *path,
+                       char ***devPaths)
+{
+    *devPaths = NULL;
+
+    if (STREQ(path, "/dev/mapper/virt")) {
+        *devPaths = g_new(char *, 4);
+        (*devPaths)[0] = g_strdup("/dev/block/8:0");  /* /dev/sda */
+        (*devPaths)[1] = g_strdup("/dev/block/8:16"); /* /dev/sdb */
+        (*devPaths)[2] = g_strdup("/dev/block/8:32"); /* /dev/sdc */
+        (*devPaths)[3] = NULL;
+    }
+
+    return 0;
+}
+
+
+int
+virGetDeviceID(const char *path, int *maj, int *min)
+{
+    init_syms();
+
+    if (STREQ(path, "/dev/mapper/virt")) {
+        *maj = 254;
+        *min = 0;
+        return 0;
+    }
+
+    return real_virGetDeviceID(path, maj, min);
+}
+
+
+bool
+virFileExists(const char *path)
+{
+    init_syms();
+
+    if (STREQ(path, "/dev/mapper/virt"))
+        return true;
+
+    return real_virFileExists(path);
+}
+
+
+int
+qemuProcessStartManagedPRDaemon(virDomainObjPtr vm G_GNUC_UNUSED)
+{
+    return 0;
+}
+
+
+void
+qemuProcessKillManagedPRDaemon(virDomainObjPtr vm G_GNUC_UNUSED)
+{
+}
diff --git a/tests/qemuhotplugtest.c b/tests/qemuhotplugtest.c
index e008c1bf0d..8b411d63f0 100644
--- a/tests/qemuhotplugtest.c
+++ b/tests/qemuhotplugtest.c
@@ -87,6 +87,8 @@ qemuHotplugCreateObjects(virDomainXMLOptionPtr xmlopt,
     virQEMUCapsSet(priv->qemuCaps, QEMU_CAPS_VNC);
     virQEMUCapsSet(priv->qemuCaps, QEMU_CAPS_SPICE);
     virQEMUCapsSet(priv->qemuCaps, QEMU_CAPS_SPICE_FILE_XFER_DISABLE);
+    virQEMUCapsSet(priv->qemuCaps, QEMU_CAPS_PR_MANAGER_HELPER);
+    virQEMUCapsSet(priv->qemuCaps, QEMU_CAPS_SCSI_BLOCK);
 
     if (qemuTestCapsCacheInsert(driver.qemuCapsCache, priv->qemuCaps) < 0)
         return -1;
@@ -750,6 +752,17 @@ mymain(void)
                    "device_del", QMP_DEVICE_DELETED("scsi3-0-5-6") QMP_OK,
                    "human-monitor-command", HMP(""));
 
+    DO_TEST_ATTACH("base-live", "disk-scsi-multipath", false, true,
+                   "object-add", QMP_OK,
+                   "human-monitor-command", HMP("OK\\r\\n"),
+                   "device_add", QMP_OK);
+    DO_TEST_DETACH("base-live", "disk-scsi-multipath", true, true,
+                   "device_del", QMP_OK,
+                   "human-monitor-command", HMP(""));
+    DO_TEST_DETACH("base-live", "disk-scsi-multipath", false, false,
+                   "device_del", QMP_DEVICE_DELETED("scsi0-0-0-0") QMP_OK,
+                   "human-monitor-command", HMP(""));
+
     DO_TEST_ATTACH("base-live", "qemu-agent", false, true,
                    "chardev-add", QMP_OK,
                    "device_add", QMP_OK);
diff --git a/tests/qemuhotplugtestdevices/qemuhotplug-disk-scsi-multipath.xml b/tests/qemuhotplugtestdevices/qemuhotplug-disk-scsi-multipath.xml
new file mode 100644
index 0000000000..5a6f955284
--- /dev/null
+++ b/tests/qemuhotplugtestdevices/qemuhotplug-disk-scsi-multipath.xml
@@ -0,0 +1,8 @@
+<disk type='block' device='lun'>
+    <driver name='qemu' type='raw'/>
+    <source dev='/dev/mapper/virt'>
+        <reservations managed='yes'/>
+    </source>
+    <target dev='sda' bus='scsi'/>
+  <address type='drive' controller='0' bus='0' target='0' unit='0'/>
+</disk>
diff --git a/tests/qemuhotplugtestdomains/qemuhotplug-base-live+disk-scsi-multipath.xml b/tests/qemuhotplugtestdomains/qemuhotplug-base-live+disk-scsi-multipath.xml
new file mode 100644
index 0000000000..40af064d10
--- /dev/null
+++ b/tests/qemuhotplugtestdomains/qemuhotplug-base-live+disk-scsi-multipath.xml
@@ -0,0 +1,62 @@
+<domain type='kvm' id='7'>
+  <name>hotplug</name>
+  <uuid>d091ea82-29e6-2e34-3005-f02617b36e87</uuid>
+  <memory unit='KiB'>4194304</memory>
+  <currentMemory unit='KiB'>4194304</currentMemory>
+  <vcpu placement='static'>4</vcpu>
+  <os>
+    <type arch='x86_64' machine='pc'>hvm</type>
+    <boot dev='hd'/>
+  </os>
+  <features>
+    <acpi/>
+    <apic/>
+    <pae/>
+  </features>
+  <clock offset='utc'/>
+  <on_poweroff>destroy</on_poweroff>
+  <on_reboot>restart</on_reboot>
+  <on_crash>restart</on_crash>
+  <devices>
+    <emulator>/usr/bin/qemu-system-x86_64</emulator>
+    <disk type='block' device='lun'>
+      <driver name='qemu' type='raw'/>
+      <source dev='/dev/mapper/virt'>
+        <reservations managed='yes'>
+          <source type='unix' path='/tmp/lib/domain-7-hotplug/pr-helper0.sock' mode='client'/>
+        </reservations>
+      </source>
+      <backingStore/>
+      <target dev='sda' bus='scsi'/>
+      <alias name='scsi0-0-0-0'/>
+      <address type='drive' controller='0' bus='0' target='0' unit='0'/>
+    </disk>
+    <controller type='usb' index='0'>
+      <alias name='usb'/>
+      <address type='pci' domain='0x0000' bus='0x00' slot='0x01' function='0x2'/>
+    </controller>
+    <controller type='ide' index='0'>
+      <alias name='ide'/>
+      <address type='pci' domain='0x0000' bus='0x00' slot='0x01' function='0x1'/>
+    </controller>
+    <controller type='scsi' index='0' model='virtio-scsi'>
+      <alias name='scsi0'/>
+      <address type='pci' domain='0x0000' bus='0x00' slot='0x03' function='0x0'/>
+    </controller>
+    <controller type='pci' index='0' model='pci-root'>
+      <alias name='pci'/>
+    </controller>
+    <controller type='virtio-serial' index='0'>
+      <alias name='virtio-serial0'/>
+      <address type='pci' domain='0x0000' bus='0x00' slot='0x04' function='0x0'/>
+    </controller>
+    <input type='mouse' bus='ps2'>
+      <alias name='input0'/>
+    </input>
+    <input type='keyboard' bus='ps2'>
+      <alias name='input1'/>
+    </input>
+    <memballoon model='none'/>
+  </devices>
+  <seclabel type='none' model='none'/>
+</domain>