diff --git a/meson.build b/meson.build
index 9842886bbb..b1b55b0d25 100644
--- a/meson.build
+++ b/meson.build
@@ -604,6 +604,12 @@ stat_functions = [
 
 functions += stat_functions
 
+open_functions = [
+  '__open_2',
+]
+
+functions += open_functions
+
 foreach function : functions
   if cc.has_function(function)
     conf.set('WITH_@0@'.format(function.to_upper()), 1)
@@ -618,6 +624,13 @@ foreach function : stat_functions
 endforeach
 
 
+foreach function : open_functions
+  if cc.has_header_symbol('fcntl.h', function)
+    conf.set('WITH_@0@_DECL'.format(function.to_upper()), 1)
+  endif
+endforeach
+
+
 # various header checks
 
 headers = [
diff --git a/tests/nssmock.c b/tests/nssmock.c
index 9ead6d8f97..3493119f3b 100644
--- a/tests/nssmock.c
+++ b/tests/nssmock.c
@@ -29,6 +29,9 @@
 # include "configmake.h"
 
 static int (*real_open)(const char *path, int flags, ...);
+# if WITH___OPEN_2
+static int (*real___open_2)(const char *path, int flags);
+# endif
 static DIR * (*real_opendir)(const char *name);
 static int (*real_access)(const char *path, int mode);
 
@@ -44,6 +47,9 @@ init_syms(void)
         return;
 
     VIR_MOCK_REAL_INIT(open);
+# if WITH___OPEN_2
+    VIR_MOCK_REAL_INIT(__open_2);
+# endif
     VIR_MOCK_REAL_INIT(opendir);
     VIR_MOCK_REAL_INIT(access);
 }
@@ -90,6 +96,26 @@ open(const char *path, int flags, ...)
     return ret;
 }
 
+# if WITH___OPEN_2
+int
+__open_2(const char *path, int flags)
+{
+    int ret;
+    char *newpath = NULL;
+
+    init_syms();
+
+    if (STRPREFIX(path, LEASEDIR) &&
+        getrealpath(&newpath, path) < 0)
+        return -1;
+
+    ret = real___open_2(newpath ? newpath : path, flags);
+
+    free(newpath);
+    return ret;
+}
+# endif
+
 DIR *
 opendir(const char *path)
 {
diff --git a/tests/qemusecuritymock.c b/tests/qemusecuritymock.c
index a6f9d6b917..80d59536b1 100644
--- a/tests/qemusecuritymock.c
+++ b/tests/qemusecuritymock.c
@@ -58,6 +58,9 @@
 
 static int (*real_chown)(const char *path, uid_t uid, gid_t gid);
 static int (*real_open)(const char *path, int flags, ...);
+#if WITH___OPEN_2
+static int (*real___open_2)(const char *path, int flags);
+#endif
 static int (*real_close)(int fd);
 #ifdef WITH_SELINUX
 static int (*real_setfilecon_raw)(const char *path, const char *context);
@@ -112,6 +115,9 @@ init_syms(void)
 
     VIR_MOCK_REAL_INIT(chown);
     VIR_MOCK_REAL_INIT(open);
+#if WITH___OPEN_2
+    VIR_MOCK_REAL_INIT(__open_2);
+#endif
     VIR_MOCK_REAL_INIT(close);
 #ifdef WITH_SELINUX
     VIR_MOCK_REAL_INIT(setfilecon_raw);
@@ -324,6 +330,24 @@ open(const char *path, int flags, ...)
 }
 
 
+#if WITH___OPEN_2
+int
+__open_2(const char *path, int flags)
+{
+    int ret;
+
+    init_syms();
+
+    if (getenv(ENVVAR)) {
+        ret = 42; /* Some dummy FD */
+    } else {
+        ret = real___open_2(path, flags);
+    }
+
+    return ret;
+}
+#endif
+
 int
 close(int fd)
 {
diff --git a/tests/vircgroupmock.c b/tests/vircgroupmock.c
index 777d60b152..d922f30f34 100644
--- a/tests/vircgroupmock.c
+++ b/tests/vircgroupmock.c
@@ -30,6 +30,9 @@
 # include "vircgroupv2devices.h"
 
 static int (*real_open)(const char *path, int flags, ...);
+# if WITH___OPEN_2
+static int (*real___open_2)(const char *path, int flags);
+# endif
 static FILE *(*real_fopen)(const char *path, const char *mode);
 static int (*real_access)(const char *path, int mode);
 static int (*real_mkdir)(const char *path, mode_t mode);
@@ -302,6 +305,9 @@ static void init_syms(void)
     VIR_MOCK_REAL_INIT(access);
     VIR_MOCK_REAL_INIT(mkdir);
     VIR_MOCK_REAL_INIT(open);
+# if WITH___OPEN_2
+    VIR_MOCK_REAL_INIT(__open_2);
+# endif
 }
 
 
@@ -589,6 +595,42 @@ int open(const char *path, int flags, ...)
     return ret;
 }
 
+# if WITH___OPEN_2
+int
+__open_2(const char *path, int flags)
+{
+    int ret;
+    char *newpath = NULL;
+
+    init_syms();
+
+    if (STREQ(path, SYSFS_CPU_PRESENT)) {
+        init_sysfs();
+        if (asprintf(&newpath, "%s/%s",
+                     fakesysfscgroupdir,
+                     SYSFS_CPU_PRESENT_MOCKED) < 0) {
+            errno = ENOMEM;
+            return -1;
+        }
+    }
+
+    if (STRPREFIX(path, SYSFS_CGROUP_PREFIX)) {
+        init_sysfs();
+        if (asprintf(&newpath, "%s%s",
+                     fakesysfscgroupdir,
+                     path + strlen(SYSFS_CGROUP_PREFIX)) < 0) {
+            errno = ENOMEM;
+            return -1;
+        }
+    }
+
+    ret = real___open_2(newpath ? newpath : path, flags);
+
+    free(newpath);
+    return ret;
+}
+# endif
+
 bool
 virCgroupV2DevicesAvailable(virCgroup *group G_GNUC_UNUSED)
 {
diff --git a/tests/virfilewrapper.c b/tests/virfilewrapper.c
index 9cdfcfdc3f..908f7142c2 100644
--- a/tests/virfilewrapper.c
+++ b/tests/virfilewrapper.c
@@ -38,6 +38,9 @@ static const char **prefixes;
 
 /* TODO: callbacks */
 static int (*real_open)(const char *path, int flags, ...);
+# if WITH___OPEN_2
+static int (*real___open_2)(const char *path, int flags);
+# endif
 static FILE *(*real_fopen)(const char *path, const char *mode);
 static int (*real_access)(const char *path, int mode);
 static int (*real_mkdir)(const char *path, mode_t mode);
@@ -54,6 +57,9 @@ static void init_syms(void)
     VIR_MOCK_REAL_INIT(access);
     VIR_MOCK_REAL_INIT(mkdir);
     VIR_MOCK_REAL_INIT(open);
+# if WITH___OPEN_2
+    VIR_MOCK_REAL_INIT(__open_2);
+# endif
 # if defined(__APPLE__) && defined(__x86_64__)
     VIR_MOCK_REAL_INIT_ALIASED(opendir, "opendir$INODE64");
 # else
@@ -176,6 +182,18 @@ int open(const char *path, int flags, ...)
     return real_open(newpath ? newpath : path, flags, mode);
 }
 
+# if WITH___OPEN_2
+int
+__open_2(const char *path, int flags)
+{
+    g_autofree char *newpath = NULL;
+
+    PATH_OVERRIDE(newpath, path);
+
+    return real___open_2(newpath ? newpath : path, flags);
+}
+# endif
+
 DIR *opendir(const char *path)
 {
     g_autofree char *newpath = NULL;
diff --git a/tests/virmock.h b/tests/virmock.h
index 300ba17174..178d0a15f0 100644
--- a/tests/virmock.h
+++ b/tests/virmock.h
@@ -27,6 +27,10 @@
 
 #include "internal.h"
 
+#ifndef WITH___OPEN_2_DECL
+int __open_2 (const char *__path, int __oflag);
+#endif
+
 #define VIR_MOCK_COUNT_ARGS(...) VIR_MOCK_ARG27(__VA_ARGS__, 26, 25, 24, 23, 22, 21, 20, 19, 18, 17, 16, 15, 14, 13, 12, 11, 10, 9, 8, 7, 6, 5, 4, 3, 2, 1)
 #define VIR_MOCK_ARG27(_1, _2, _3, _4, _5, _6, _7, _8, _9, _10, _11, _12, _13, _14, _15, _16, _17, _18, _19, _20, _21, _22, _23, _24, _25, _26, _27, ...) _27
 #define VIR_MOCK_ARG_PASTE(a, b, ...) a##b(__VA_ARGS__)
diff --git a/tests/virpcimock.c b/tests/virpcimock.c
index 2f98b0cf13..5b923c63ce 100644
--- a/tests/virpcimock.c
+++ b/tests/virpcimock.c
@@ -36,9 +36,9 @@
 
 static int (*real_access)(const char *path, int mode);
 static int (*real_open)(const char *path, int flags, ...);
-# ifdef __GLIBC__
+# if WITH___OPEN_2
 static int (*real___open_2)(const char *path, int flags);
-# endif /* ! __GLIBC__ */
+# endif /* ! WITH___OPEN_2 */
 static int (*real_close)(int fd);
 static DIR * (*real_opendir)(const char *name);
 static char *(*real_virFileCanonicalizePath)(const char *path);
@@ -945,9 +945,9 @@ init_syms(void)
 
     VIR_MOCK_REAL_INIT(access);
     VIR_MOCK_REAL_INIT(open);
-# ifdef __GLIBC__
+# if WITH___OPEN_2
     VIR_MOCK_REAL_INIT(__open_2);
-# endif /* ! __GLIBC__ */
+# endif /* WITH___OPEN_2 */
     VIR_MOCK_REAL_INIT(close);
 # if defined(__APPLE__) && defined(__x86_64__)
     VIR_MOCK_REAL_INIT_ALIASED(opendir, "opendir$INODE64");
@@ -1110,12 +1110,7 @@ open(const char *path, int flags, ...)
 }
 
 
-# ifdef __GLIBC__
-/* in some cases this function may not be present in headers, so we need
- * a declaration to silence the compiler */
-int
-__open_2(const char *path, int flags);
-
+# if WITH___OPEN_2
 int
 __open_2(const char *path, int flags)
 {
@@ -1139,7 +1134,7 @@ __open_2(const char *path, int flags)
 
     return ret;
 }
-# endif /* ! __GLIBC__ */
+# endif /* WITH___OPEN_2 */
 
 DIR *
 opendir(const char *path)
diff --git a/tests/virtestmock.c b/tests/virtestmock.c
index 19559aee7a..5b25b380e5 100644
--- a/tests/virtestmock.c
+++ b/tests/virtestmock.c
@@ -29,6 +29,9 @@
 #include "virfile.h"
 
 static int (*real_open)(const char *path, int flags, ...);
+#if WITH___OPEN_2
+static int (*real___open_2)(const char *path, int flags);
+#endif
 static FILE *(*real_fopen)(const char *path, const char *mode);
 static int (*real_access)(const char *path, int mode);
 static int (*real_connect)(int fd, const struct sockaddr *addr, socklen_t addrlen);
@@ -44,6 +47,9 @@ static void init_syms(void)
         return;
 
     VIR_MOCK_REAL_INIT(open);
+#if WITH___OPEN_2
+    VIR_MOCK_REAL_INIT(__open_2);
+#endif
     VIR_MOCK_REAL_INIT(fopen);
     VIR_MOCK_REAL_INIT(access);
     VIR_MOCK_REAL_INIT(connect);
@@ -153,6 +159,20 @@ int open(const char *path, int flags, ...)
     return ret;
 }
 
+
+#if WITH___OPEN_2
+int
+__open_2(const char *path, int flags)
+{
+    init_syms();
+
+    CHECK_PATH(path);
+
+    return real___open_2(path, flags);
+}
+#endif
+
+
 FILE *fopen(const char *path, const char *mode)
 {
     init_syms();
diff --git a/tests/virusbmock.c b/tests/virusbmock.c
index 570f7c28eb..e148296b7c 100644
--- a/tests/virusbmock.c
+++ b/tests/virusbmock.c
@@ -30,6 +30,9 @@
 #define FAKE_USB_SYSFS "virusbtestdata/sys_bus_usb"
 
 static int (*real_open)(const char *pathname, int flags, ...);
+#if WITH___OPEN_2
+static int (*real___open_2)(const char *path, int flags);
+#endif
 static DIR *(*real_opendir)(const char *name);
 
 static void init_syms(void)
@@ -38,6 +41,9 @@ static void init_syms(void)
         return;
 
     VIR_MOCK_REAL_INIT(open);
+#if WITH___OPEN_2
+    VIR_MOCK_REAL_INIT(__open_2);
+#endif
     VIR_MOCK_REAL_INIT(opendir);
 }
 
@@ -90,3 +96,19 @@ int open(const char *pathname, int flags, ...)
     ret = real_open(path, flags, mode);
     return ret;
 }
+
+#if WITH___OPEN_2
+int
+__open_2(const char *pathname, int flags)
+{
+    g_autofree char *path = NULL;
+
+    init_syms();
+
+    path = get_fake_path(pathname);
+    if (!path)
+        return -1;
+
+    return real_open(path, flags);
+}
+#endif