diff --git a/src/conf/domain_validate.c b/src/conf/domain_validate.c
index ac32fa1477..e423383e22 100644
--- a/src/conf/domain_validate.c
+++ b/src/conf/domain_validate.c
@@ -2221,6 +2221,7 @@ static int
 virDomainMemoryDefValidate(const virDomainMemoryDef *mem,
                            const virDomainDef *def)
 {
+    const long pagesize = virGetSystemPageSize();
     unsigned long long thpSize;
 
     /* Guest NUMA nodes are continuous and indexed from zero. */
@@ -2295,6 +2296,14 @@ virDomainMemoryDefValidate(const virDomainMemoryDef *mem,
                            _("virtio-pmem does not support NUMA nodes"));
             return -1;
         }
+
+        if (pagesize > 0 &&
+            mem->target.virtio_pmem.address % pagesize != 0) {
+            virReportError(VIR_ERR_CONFIG_UNSUPPORTED,
+                           _("memory address must be aligned to %1$ld bytes"),
+                           pagesize);
+            return -1;
+        }
         break;
 
     case VIR_DOMAIN_MEMORY_MODEL_VIRTIO_MEM: