diff --git a/src/security/security_apparmor.c b/src/security/security_apparmor.c
index 122edd4df1..0aff794a9a 100644
--- a/src/security/security_apparmor.c
+++ b/src/security/security_apparmor.c
@@ -831,7 +831,17 @@ AppArmorSetSecurityHostdevLabel(virSecurityManagerPtr mgr,
         if (!pci)
             goto done;
 
-        ret = virPCIDeviceFileIterate(pci, AppArmorSetSecurityPCILabel, ptr);
+        if (dev->source.subsys.u.pci.backend
+            == VIR_DOMAIN_HOSTDEV_PCI_BACKEND_TYPE_VFIO) {
+            char *vfioGroupDev = virPCIDeviceGetVFIOGroupDev(pci);
+
+            if (!vfioGroupDev)
+                goto done;
+            ret = AppArmorSetSecurityPCILabel(pci, vfioGroupDev, ptr);
+            VIR_FREE(vfioGroupDev);
+        } else {
+            ret = virPCIDeviceFileIterate(pci, AppArmorSetSecurityPCILabel, ptr);
+        }
         virPCIDeviceFree(pci);
         break;
     }
diff --git a/src/security/security_dac.c b/src/security/security_dac.c
index 8576081b2d..5e00112d10 100644
--- a/src/security/security_dac.c
+++ b/src/security/security_dac.c
@@ -516,8 +516,19 @@ virSecurityDACSetSecurityHostdevLabel(virSecurityManagerPtr mgr,
         if (!pci)
             goto done;
 
-        ret = virPCIDeviceFileIterate(pci, virSecurityDACSetSecurityPCILabel,
-                                      params);
+        if (dev->source.subsys.u.pci.backend
+            == VIR_DOMAIN_HOSTDEV_PCI_BACKEND_TYPE_VFIO) {
+            char *vfioGroupDev = virPCIDeviceGetVFIOGroupDev(pci);
+
+            if (!vfioGroupDev)
+                goto done;
+            ret = virSecurityDACSetSecurityPCILabel(pci, vfioGroupDev, params);
+            VIR_FREE(vfioGroupDev);
+        } else {
+            ret = virPCIDeviceFileIterate(pci, virSecurityDACSetSecurityPCILabel,
+                                          params);
+        }
+
         virPCIDeviceFree(pci);
 
         break;
@@ -596,7 +607,17 @@ virSecurityDACRestoreSecurityHostdevLabel(virSecurityManagerPtr mgr,
         if (!pci)
             goto done;
 
-        ret = virPCIDeviceFileIterate(pci, virSecurityDACRestoreSecurityPCILabel, mgr);
+        if (dev->source.subsys.u.pci.backend
+            == VIR_DOMAIN_HOSTDEV_PCI_BACKEND_TYPE_VFIO) {
+            char *vfioGroupDev = virPCIDeviceGetVFIOGroupDev(pci);
+
+            if (!vfioGroupDev)
+                goto done;
+            ret = virSecurityDACRestoreSecurityPCILabel(pci, vfioGroupDev, mgr);
+            VIR_FREE(vfioGroupDev);
+        } else {
+            ret = virPCIDeviceFileIterate(pci, virSecurityDACRestoreSecurityPCILabel, mgr);
+        }
         virPCIDeviceFree(pci);
 
         break;
diff --git a/src/security/security_selinux.c b/src/security/security_selinux.c
index a8b74eebcc..a5b54cb821 100644
--- a/src/security/security_selinux.c
+++ b/src/security/security_selinux.c
@@ -1342,7 +1342,17 @@ virSecuritySELinuxSetSecurityHostdevSubsysLabel(virDomainDefPtr def,
         if (!pci)
             goto done;
 
-        ret = virPCIDeviceFileIterate(pci, virSecuritySELinuxSetSecurityPCILabel, def);
+        if (dev->source.subsys.u.pci.backend
+            == VIR_DOMAIN_HOSTDEV_PCI_BACKEND_TYPE_VFIO) {
+            char *vfioGroupDev = virPCIDeviceGetVFIOGroupDev(pci);
+
+            if (!vfioGroupDev)
+                goto done;
+            ret = virSecuritySELinuxSetSecurityPCILabel(pci, vfioGroupDev, def);
+            VIR_FREE(vfioGroupDev);
+        } else {
+            ret = virPCIDeviceFileIterate(pci, virSecuritySELinuxSetSecurityPCILabel, def);
+        }
         virPCIDeviceFree(pci);
 
         break;
@@ -1504,7 +1514,17 @@ virSecuritySELinuxRestoreSecurityHostdevSubsysLabel(virSecurityManagerPtr mgr,
         if (!pci)
             goto done;
 
-        ret = virPCIDeviceFileIterate(pci, virSecuritySELinuxRestoreSecurityPCILabel, mgr);
+        if (dev->source.subsys.u.pci.backend
+            == VIR_DOMAIN_HOSTDEV_PCI_BACKEND_TYPE_VFIO) {
+            char *vfioGroupDev = virPCIDeviceGetVFIOGroupDev(pci);
+
+            if (!vfioGroupDev)
+                goto done;
+            ret = virSecuritySELinuxRestoreSecurityPCILabel(pci, vfioGroupDev, mgr);
+            VIR_FREE(vfioGroupDev);
+        } else {
+            ret = virPCIDeviceFileIterate(pci, virSecuritySELinuxRestoreSecurityPCILabel, mgr);
+        }
         virPCIDeviceFree(pci);
 
         break;