The libvirt VirtualBox driver can manage any VirtualBox version from version 2.2 onwards.
The libvirt VirtualBox driver provides per-user drivers (the "session" instance). The uri of the driver protocol is "vbox". Some example connection URIs for the driver are:
vbox:///session (local access to per-user instance) vbox+unix:///session (local access to per-user instance) vbox+tcp://user@example.com/session (remote access, SASl/Kerberos) vbox+ssh://user@example.com/session (remote access, SSH tunnelled)
<domain type='vbox'> <name>vbox</name> <uuid>4dab22b31d52d8f32516782e98ab3fa0</uuid> <os> <type>hvm</type> <boot dev='cdrom'/> <boot dev='hd'/> <boot dev='fd'/> <boot dev='network'/> </os> <memory>654321</memory> <vcpu>1</vcpu> <features> <pae/> <acpi/> <apic/> </features> <devices> <disk type='file' device='cdrom'> <source file='/home/user/Downloads/slax-6.0.9.iso'/> <target dev='hdc'/> <readonly/> </disk> <disk type='file' device='disk'> <source file='/home/user/tmp/vbox.vdi'/> <target dev='hdd'/> </disk> <disk type='file' device='floppy'> <source file='/home/user/tmp/WIN98C.IMG'/> <target dev='fda'/> </disk> <!--BRIDGE--> <interface type='bridge'> <source bridge='eth0'/> <mac address='00:16:3e:5d:c7:9e'/> <model type='am79c973'/> </interface> <!--NAT--> <interface type='user'> <mac address='56:16:3e:5d:c7:9e'/> <model type='82540eM'/> </interface> <sound model='sb16'/> <parallel type='dev'> <source path='/dev/pts/1'/> <target port='0'/> </parallel> <parallel type='dev'> <source path='/dev/pts/2'/> <target port='1'/> </parallel> <serial type="dev"> <source path="/dev/ttyS0"/> <target port="0"/> </serial> <serial type="pipe"> <source path="/tmp/serial.txt"/> <target port="1"/> </serial> <hostdev mode='subsystem' type='usb'> <source> <vendor id='0x1234'/> <product id='0xbeef'/> </source> </hostdev> <hostdev mode='subsystem' type='usb'> <source> <vendor id='0x4321'/> <product id='0xfeeb'/> </source> </hostdev> </devices> </domain>